Personally, if you're not planning on taking that bike on track, there's no reason to get an M over an S other than for bragging rights. The current S bikes already have a few bits from the M such as the cylinder heads/air box, quick throttle, and much of the suspension geometry.
I was looking at that decision when I got my 22 K67. When the details came out about what was different between the S and M at that time (which was greater than it is now), it wasn't worth the price differential. I have zero regrets with my "lowly" S bike.
ETA: On the Panigale, you might want to do some digging about the rear brake line/rear wheel speed sensor issue. I ran across a video where the location of the exhaust is cooking at least the brake line. Apparently, the only fix right now from Ducati is to keep replacing the brake line. The video I saw also saw heat damage to the wiring for the speed sensor. The author of the video decided to do his own fix by using heat shielding tape. He mentioned this has been a problem with other owners. I haven't looked much into it personally as I don't have any desire to own another Ducati again after my experience with an 848 I have since sold.
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